Match 6 numbers

Royal Challengers Bangalore

2012.09.14 11:46 edwardpattison87 Royal Challengers Bangalore

Welcome to /RCB! The official subreddit of Royal Challengers Bangalore. For Match Threads. Analysis. Strategies & Memes. 🏏
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2008.05.27 13:06 The back page of the internet.

The football subreddit. News, results and discussion about the beautiful game.
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2011.10.27 23:49 soullimbo Rainbow Six

Welcome to the Rainbow Six subreddit, a community for R6 fans to discuss Rainbow Six Siege and past favorites.
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2023.05.28 09:11 Agmion Tell me he’s not cheating

Tell me he’s not cheating
I played this match about 10 minutes ago. In round 6 he played Hulk, Abonimation and Misty Knight. There was no extra energy involved.
In total you have 21 energy per game.
His cards:
1 Sunspot 1 Misty Knight 2 Cage 2 Shocker 2 Hazmat 3 Cyclops 4 Thing 5 Abonimation 6 Hulk
That’s 26 energy total. Am I missing something? I don’t think so but who knows…
I wanted to report him but the reporting mask on iPhone is the greatest @&€“ I’ve ever seen.
So what do you think? Is he a cheater? And if yes, can you please help me to report this so he gets banned?
Have a nice day!
submitted by Agmion to MarvelSnap [link] [comments]


2023.05.28 09:10 dekudeals Blasphemous – $6.24 (75% off, matches previous low)

Blasphemous – $6.24 (75% off, matches previous low) submitted by dekudeals to dekudeals [link] [comments]


2023.05.28 09:10 hannahduffyx Backpacker looking to do international transfer with different currencies

Hello everyone , so I’m backpacking in Australia , originally from the U.K. I’m looking to do an online course that is 585 USD dollars per month for 6 Months.
Most of my money is held in my aus account.
What is the most cost effective way to set up this transfer..
I was thinking of adding aus dollars to my wise account and then using my wise card number to pay the usd per month .. or something similar with revolut. It doesn’t make sense to me to transfer aus dollars to gbp then to usd due to exchange rates and fees ? Any advice please on the best way to go about this.
Is revolut or wise better for this? Thank you v much
submitted by hannahduffyx to backpacking [link] [comments]


2023.05.28 09:09 Veto_Corleone Dybala will soon turn 36. Should I keep him for 1 more season after the current season or replace him? I have another prospect ready to replace him. He is currently my vice captain and he is performing quite good for his age. I'm afraid the dressing room atmosphere will be spoilt if he is let go.

Dybala will soon turn 36. Should I keep him for 1 more season after the current season or replace him? I have another prospect ready to replace him. He is currently my vice captain and he is performing quite good for his age. I'm afraid the dressing room atmosphere will be spoilt if he is let go. submitted by Veto_Corleone to footballmanagergames [link] [comments]


2023.05.28 09:08 nskdnnm Tempered glass on S23+

I finally pulled the trigger on an S23+ and it'll arrive in a few days. Reading online, it seems like the Victus2 is VERY prone to micro scratches, even in a pocket, so I'm considering a tempered glass protection. Now, my experience with glass protection isn't the greatest and I haven't used one with my current S9+. What I don't like about them is (itemized and numbered for easy quote):
  1. way too many brands and types, difficult to decide which type is ideal. Anti-glare, anti-scratch, thickness, compatibility with cases, oleophobic, etc...
  2. applying them with micro dust on the screen/bubbles.
  3. what's this glue some protectors ship with? Is it going to damage the screen oleophobic coat once I remove it? Is it easy to remove if badly applied or broken, or will I need a heat gun?
4 do tempered glass that stick without glue exist? Should I prefer those over the glue ones?
  1. Everything considered, should I still go for a screen protector? I'm extremely careful with my devices, especially during the first 2 years at least, but I do keep them in pockets of course. Is the screen gonna look like rubbish after a year? The plan is to keep this phone as long as possible (5 years maybe) as I HATE transferring everything over to a new device and setting it up to my preference.
  2. Should I cancel the order and go for an iPhone instead? Yeah, that's a joke, obviously. I'd rather have a N3310.
I live in Asia, so while I do appreciate brand recommendations, I most likely won't find your favorite brands here, or it'll take too long to ship in this part of the world. If you can, please recommends the features a tempered glass should have.
Any help is much appreciated.
submitted by nskdnnm to S23 [link] [comments]


2023.05.28 09:08 inafishbowl17 Cheap Maple charcoal filter set up.

Cheap Maple charcoal filter set up.
I've been using a $20 PUR filter pitcher to polish my shine. Filters are 3 for $18 at wally world. Heads and tails can be cleaned up going thru 2 or 3 times. Couple observations. The filter gets gummed up after 6-10 cycles. I usually filter hot water thru it a few times to clean it up. You can smell the nasty stuff the first cleaning. The second or third time, the water smells much better.
As far as the charcoal filter I made one using Maple smoker chips. The famous old number 7 place uses maple for its charcoal filtering. I used two 2 liter soda bottles. Cut the bottom off one invert it and use the second as a collection vessel. A coffee filter jammed into the neck. FERNCO makes a coupler that's perfect. One end w the clamp slips over the outside of the top bottle and the other fits inside the collection bottle without a clamp and is convienient for easy removal. It gets cleaner as you run thru it more. 2 or 3 cycles it totally changes the taste of the shine and its very close to Tennessee whiskey.
submitted by inafishbowl17 to firewater [link] [comments]


2023.05.28 09:08 kluz885 Massive improvements from Estrogen (E2) gel/injections and hops

TLDR and my log is at the end.
Hi all just wanted to share my breakthrough regimen that has resulted in excellent improvements in sexual function as well as some improvement in the anhedonia category. The anhedonia i believe is not caused by PSSD or it had very little to do with it. Regardless, it does seem to have improved mostly the feeling of being able to connect with females. I was targeting sexual function improvements. I took a combination of E2 injections, E2 gel and hops supplement. Everything else had been stable for a minimum of 6 months. Attached a document below that i recorded my trial on. It's now been a month+ since i last used E2 and very rarely do i take hops anymore. Improvements have stuck and seem to be getting better. Big improvements in erection quality, sensitivity and less so in libido.

I'll try to quantify the improvements but its difficult. As always things will fluctuate based on other factors like sleep, attractiveness of girl, mood that day, stress etc. The "Before" will be my baseline which was a combination of various supplements and medications. The heavy hitters are TRT (~125mg/week split into 2 doses Monday and Thursday), bromantane, NA Semax, selegiline in no particular order. Viagra is often used before sex as well. After my E2 trial i no longer need viagra all the time. Normally I am having sex almost daily which can be a bit taxing on the body i think. The sensitivity improvements are problematic on occasion. It becomes difficult to continue to have sex and i have to use tricks and techniques to not cum too quickly. I dont wish to try E2 again for the time being as the increased sensitivity causes issues.
The lower the score the worse it is. 1/10 sensitivity would be near total genital numbness and no pleasure.10/10 would be pre-PSSD levels for me that align with the best I've felt in my life in that area. It's not the most scientific approach if anyone has a proper form to fill out for recovery I could give it a go.
Before
Erection quality (being able to get an erection and maintain it during sex) 5/10
Libido - 3/10
Sensitivity - 5/10
Anhedonia - 7/10
Refractory Period - 1 day (assuming having sex daily)
After
Erection quality (being able to get an erection and maintain it during sex) 8/10
Libido - 5/10
Sensitivity - 8/10
Anhedonia - 8/10
Refractory Period - Varies, limited data. 1-2 hours has been possible on several occasions so far. Definite improvement


A big thanks to u/Sweaty_Literature_69 (Spyros) for sharing his theory
TLDR: Took E2 injections/gel and hops and got big improvements in sexual function across the board that have stuck for a month+

---------Log Below-------

-------------------------------

  1. mike1 — 03/20/2023 1:31 PM
Just applied 1.25g (0.75mg of 17 β estradiol) gel to test the waters about 40 minutes ago. will see if there's any effects i wont be doing a proper trial (following sweaty's pdf) because there's too many restrictions. will try with the gel for now and then move to injections later perhaps Some background: Ive been on trt for 2-3 years already. I've had PSSD for ~3 years from prozac (fluoxetine). Ive tried many things to see what will work for me. I would say I experienced a 30-40% improvement from baseline with my current regimen. The best window I ever had was my initial dose of proviron which prompted me to give this theory a shot. This lasted 2 days or so. I felt like a God every aspect was improved. It wasn't a manic phase though. Current regimen (the heavy hitters): TRT ~125mg/week No HCG NA Semax 300-600mcg/day Bromantane varying dosages Selegiline 1.25mg/day sublingual Various other supplements that I dont think matter all that much. Sexmas, Bromantane, Selegiline were all added individually after 1-2month minimum baseline was established. (edited)
2.
Akas — 03/20/2023 2:52 PM
May i ask why you didn’t pair Test with HCG from the beginning to prevent ball shrinkage?
  1. [2:53 PM]
And may i also ask which Ssri you took, how long you took it for and how hold you are?
4.
mike1 — 03/20/2023 3:21 PM
May i ask why you didn’t pair Test with HCG from the beginning to prevent ball shrinkage? - I have 0 sperm count now which is very useful for unprotected sex. I have used hcg in the past. And may i also ask which Ssri you took, how long you took it for and how hold you are? - Fluoxetine for ~12 years, 30 years old
5.
Akas — 03/20/2023 3:33 PM
So you are dealing with sexual symptoms right now? But you have recovered some of your sexuality/libido? (edited)
6.
mike1 — 03/20/2023 3:41 PM
yea mostly just sexual symptoms and some aspects of anhedonia but im not a severe case. i can have sex daily if i use viagra. i dont have much libido the brain to dick connection isnt there much and genital numbness
  1. u/mike1
yea mostly just sexual symptoms and some aspects of anhedonia but im not a severe case. i can have sex daily if i use viagra. i dont have much libido the brain to dick connection isnt there much and genital numbness
14.
mike1 — 03/20/2023 6:31 PM
Update 1: Roughly 5 hours since gel application. Had a little surge in genital/skin sensitivity around the 1 hour mark. Feel like i am beginning to retain water and blood pressure going up a bit. Nothing uncomfortable but its noticeable. Better sense of well being around the 2-3 hour mark which has faded. No other side effects or improvements to note. (edited)
  1. [7:23 PM]
What are your current doses ?
  1. u/mike1
Update 1: Roughly 5 hours since gel application. Had a little surge in genital/skin sensitivity around the 1 hour mark. Feel like i am beginning to retain water and blood pressure going up a bit. Nothing uncomfortable but its noticeable. Better sense of well being around the 2-3 hour mark which has faded. No other side effects or improvements to note. (edited)
Survivor — 03/20/2023 7:43 PM
Blackcreative also had the same reaction after 5 hours
  1. u/Zyzz Brah
What are your current doses ?
mike1 — 03/20/2023 9:59 PM
dosage is posted. first line in the first post
20.
Survivor — 03/20/2023 10:01 PM
u/mike1 are you gonna use this amount of gel daily for your current protocol?
21.
mike1 — 03/20/2023 10:05 PM
The bioavailability of oestradiol from the gel was 61% - https://pubmed.ncbi.nlm.nih.gov/10465378/
PubMed
Absorption and bioavailability of oestradiol from a gel, a patch an...
The doses used of the transdermal gel and the patch roughly corresponded to each other with regard to the amount of oestradiol absorbed whereas the bioavailability from the tablet was significantly higher than from the gel. The lack of bioequivalence, the different serum oestradiol profiles and the …
📷
  1. u/Survivor
u/mike1 are you gonna use this amount of gel daily for your current protocol?
mike1 — 03/20/2023 10:07 PM
i think ill increase it tomorrow to 1.6mg of 17 β estradiol. that should mean roughly 1mg is absorbed (edited)
  1. [10:07 PM]
double today's dosage
24.
Survivor — 03/20/2023 10:07 PM
What is the bioavailability of gels usually?
  1. mike1
The bioavailability of oestradiol from the gel was 61% - https://pubmed.ncbi.nlm.nih.gov/10465378/
mike1 — 03/20/2023 10:08 PM
i dont know. i just posted the bioavailability of E2 gel
  1. [10:08 PM]
depends on what body part you put it on too
  1. [10:08 PM]
i did inner thigh
  1. u/mike1
depends on what body part you put it on too
Survivor — 03/20/2023 10:08 PM
Where is it the highest?
29.
mike1 — 03/20/2023 10:09 PM
i read inner thigh, inner upper arms is good
  1. [10:11 PM]
Update 2: Around 9 hours since application. No changes, no improvements/side effects. Had sex with viagra as normal. Seemed to have better sensitivity, bit more libido than yesterday. No crazy improvements though. My sexual function fluctuates ive had days like this before. If i could have this level of function consistently though that'd be a marked improvement.
March 21, 2023
31.
mike1 — 03/21/2023 8:26 PM
Update 3: Applied roughly 1.6mg of 17 β estradiol gel 5 hours ago so roughly 1mg is absorbed. No changes to report. No improvements, no side effects. Will try to get injections soon see if that helps. May add in hops too.
March 27, 2023
34.
Update 4: Applied roughly 1mg of 17 β estradiol gel 4 hours ago an d 1240mg hops. No changes to report. No improvements, no side effects. seems improvements have stopped. what little improvements there were anyways will keep going. but this doesnt seem to be the magic bullet i had my best ever window years ago on proviron. must be some hormone combo that will fix it mike1 — 25/03/2023 19:25 Update 5: Applied roughly 1mg of 17 β estradiol gel yesterday and took 1240mg hops again. No changes to report. No improvements, no side effects.
36.
mike1 — 03/27/2023 5:03 PM
thanks. just got oestradiol benzoate today for injection. injected 1mg 5 mins ago will report back later
  1. [5:04 PM]
i am not on hcg btw. if you want to edit the title
  1. [5:04 PM]
on TRT, e2 gel, now e2 injections
  1. u/mike1
The bioavailability of oestradiol from the gel was 61% - https://pubmed.ncbi.nlm.nih.gov/10465378/
Matiyar — 03/27/2023 5:08 PM
61% as compared to a pill ,-,
  1. [5:10 PM]
Biovailability of oral estradiol ranges from less than 1% to around 15%, so according to this research you can expect ~9% absorption at best
43.
mike1 — 03/27/2023 5:14 PM
really? that seems incredibly low, almost useless
  1. [5:15 PM]
his cream is 85% he says
46.
Matiyar — 03/27/2023 5:20 PM
I don't know from where he pulled that number
  1. u/Matiyar
I don't know from where he pulled that number
mike1 — 03/27/2023 5:21 PM
i would guess the manufacturer? ill ask him
48.
Survivor — 03/27/2023 10:07 PM
u/mike1 When did you stopped e2 gel?
49.
Ratatouileee — 03/27/2023 11:50 PM
u/mike1 any different feeling?
March 28, 2023
  1. u/Survivor
u/mike1 When did you stopped e2 gel?
mike1 — 03/28/2023 12:17 AM
yesterday
  1. u/Ratatouileee
u/mike1 any different feeling?
mike1 — 03/28/2023 12:19 AM
Update 6: Injected 1mg of estradiol benzoate. Today was also my day for TRT injection. 1 hour in feel more sensitivty, hard flaccid type dick (this a positive). dick feels more full. It persisted for a few hours then declined. Had great sex, increased sensitivity, more libido. Maybe a 15% improvement so far over baseline so far. I feel the most effects shortly after injection and shortly after applying the gel. (edited)
Survivor — 03/28/2023 12:22 AM
Awesome man
53.
Dixon Uranus — 03/28/2023 1:07 AM
Great news, bro!
  1. [1:07 AM]
Do you have cognitive or emotional symptoms at all?
  1. [1:08 AM]
If yes, any changes on these fronts as well?
56.
mike1 — 03/28/2023 10:37 AM
I might have some degree of anhedonia. I believe ive had it since a young age before ssri though. I cant feel love/connections but again a problem since i was young. Still can feel a range of emotions but im mostly in the middle not many ups and downs. Cognitive im fine. No changes there. Bromanatane and semax helped my cognitive aspects already. Still on those.
57.
Survivor — 03/28/2023 12:44 PM
u/mike1 Are you gonna continue estradiol benzoate im?
58.
mike1 — 03/28/2023 2:14 PM
yea my plan is to do a week
59.
Ratatouileee — 03/28/2023 3:38 PM
u/mike1 have you had windows before you started the estrogen or is this the first time you got your libido and sensitivity back?
  1. u/Ratatouileee
u/mike1 have you had windows before you started the estrogen or is this the first time you got your libido and sensitivity back?
mike1 — 03/28/2023 3:43 PM
from my OP: "The best window I ever had was my initial dose of proviron which prompted me to give this theory a shot. This lasted 2 days or so. I felt like a God every aspect was improved. It wasn't a manic phase though."
61.
138791 — 03/28/2023 3:51 PM
I felt the same from mini recoveries
62.
Survivor — 03/28/2023 8:26 PM
u/mike1 Any update today?
  1. u/mike1
Update 6: Injected 1mg of estradiol benzoate. Today was also my day for TRT injection. 1 hour in feel more sensitivty, hard flaccid type dick (this a positive). dick feels more full. It persisted for a few hours then declined. Had great sex, increased sensitivity, more libido. Maybe a 15% improvement so far over baseline so far. I feel the most effects shortly after injection and shortly after applying the gel. (edited)
LastRiver — 03/28/2023 9:08 PM
Sorry man I'm confused by your wording. Are you saying hard flaccid is a positive? I don't think I'm understanding right lol
  1. u/LastRiver
Sorry man I'm confused by your wording. Are you saying hard flaccid is a positive? I don't think I'm understanding right lol
mike1 — 03/28/2023 11:14 PM
yea it is in this context. imagine a hard flaccid as your baseline during the day vs a shrunken dick. when i had sex i was able to have a strong erection with a small dose of viagra
  1. u/Survivor
u/mike1 Any update today?
mike1 — 03/28/2023 11:14 PM
i was busy today and forgot to inject. didnt realize until it was late evening time
  1. u/mike1
yea it is in this context. imagine a hard flaccid as your baseline during the day vs a shrunken dick. when i had sex i was able to have a strong erection with a small dose of viagra
LastRiver — 03/28/2023 11:24 PM
Hard flaccid is a shrunken dick
  1. u/mike1
i was busy today and forgot to inject. didnt realize until it was late evening time
Survivor — 03/28/2023 11:31 PM
Your e2 levels must be peaking tomorrow after 48 hours
  1. u/LastRiver
Hard flaccid is a shrunken dick
mike1 — 03/28/2023 11:35 PM
Opposite of that. Its semi hard, hands wells, but not an erection
March 29, 2023
70.
mike1 — 03/29/2023 6:45 PM
i injected around an hour ago. will report later
71.
  1. u/mike1
Update 6: Injected 1mg of estradiol benzoate. Today was also my day for TRT injection. 1 hour in feel more sensitivty, hard flaccid type dick (this a positive). dick feels more full. It persisted for a few hours then declined. Had great sex, increased sensitivity, more libido. Maybe a 15% improvement so far over baseline so far. I feel the most effects shortly after injection and shortly after applying the gel. (edited)
mike1 — 03/30/2023 9:05 PM
Update 7: injected 1mg yesterday. Improvements thus far have stuck. No improvements beyond what i reported before. Today no injection. (edited)
April 1, 2023
76.
mike1 — 04/01/2023 11:51 AM
sexual function not as good yesterday. was a bit stressed too
April 2, 2023
79.
mike1 — 04/02/2023 3:57 PM
Update 8: Today is day 4 of no injection. Nothing to report. Maybe a 5% improvement has stuck from my E2 usage prior (edited)
April 3, 2023
82.
mike1 — 04/03/2023 3:41 PM
Update 9: Day 5 of no injection. Performance was good last night. Definitely better than normal. Feeling good today will see how performance is tonight.
83.
Survivor — 04/03/2023 4:08 PM
u/mike1 It’s good you are seeing improvements. I pray to god that this might be the key for all of us .
  1. u/mike1
Update 9: Day 5 of no injection. Performance was good last night. Definitely better than normal. Feeling good today will see how performance is tonight.
April 4, 2023
  1. u/mike1
Update 9: Day 5 of no injection. Performance was good last night. Definitely better than normal. Feeling good today will see how performance is tonight.
Akas — Yesterday at 7:50 AM
That’s dope. Your libido/sex drive is feeling high?
88.
mike1 — Yesterday at 11:44 AM
not high. just better than normal. i would say erection quality and sensitivity is the most improved. libido still low
  1. u/Survivor
You must be a hyper responder getting improvement with such low dose initially
mike1 — Yesterday at 7:36 PM
low dose of what?
  1. u/mike1
low dose of what?
Survivor — Yesterday at 7:55 PM
E2
92.
mike1 — Yesterday at 8:09 PM
hmm i dont think its a low dose. maybe compared to what other people are doing. but more e2 than you would get from TRT or a big test injection.
April 5, 2023
93.
mike1 — Today at 2:45 PM
Update 10: Today is day 7 of no E2 injections. I have been taking hops before sleeping on occasion the last few days. Performance is better than normal for sure. Maybe a 15% improvement for erection quality and sensitivity has stuck so far at this point. I will be starting NAC+Sarcosine tomorrow
Final update 28/4/2023 – I have been on NAC+Sarcosine and around 900mg of hops per day. It has been 4 weeks since I began E2 or hops. Sensitivity improvements have stayed. Better erections, slightly more libido. Libido is still low otherwise I am very happy with my improvements.
submitted by kluz885 to PSSD [link] [comments]


2023.05.28 09:07 No-Tumbleweed-5377 PPV Path: The Elite vs BCC Anarchy In The Arena

The Elite
Kenny Omega
Record: 7-7
Hangman Adam Page
Record: 9-6
The Young Bucks
Record: 7-10
Blackpool Combat Club
Jon Moxley
Record: 9-6
Bryan Danielson
Record: 1-5
Claudio Castagnoli
Record: 1-2
Wheeler Yuta
Record: 0-2
submitted by No-Tumbleweed-5377 to AEWOfficial [link] [comments]


2023.05.28 09:04 hippotrouble Veloster N seatbelt swap?

Just saw these blue Veloster N seatbelt parts and wondered if they'd fit the Kona N:
https://sharkracing.com/2019-veloster-factory-genuine-performance-blue-seat-belt-set/
Tried to find part numbers for stuff to see if things would match but my googlefu is weak for that apparently. Also no clue if there'd be other parts required or whatever.
(I know there's companies that do belt replacements but the ones I've seen ask you to send your original units...I'd rather not be without my seatbelts for however many days the turnaround time it)
submitted by hippotrouble to KonaN_ [link] [comments]


2023.05.28 09:02 RLMatchThreads [RLCS APAC] Spring Cup Day 2 of 2 Event Thread

RLCS 22-23: Asia-Pacific

Regional 2 Day UTC
Rounds 1 & 2 Sat 08:00
Playoffs - Top 8 Sun 08:00 Today
RLCS 2022-23 Guide

Coverage

Official Bracket
Liquipedia / / ShiftRLE.gg

Streams

Platforms Link Language
Twitch RocketLeagueAPAC ENG
Twitch Kokken JPN

Results

Elimination UTC Liquipedia Bracket
▼ Upper Bracket Semifinals (Bo7)
Gladiators 08:00 UTC Paradigm
Elevate 08:00 UTC Nimmt55
▼ Lower Bracket Quarterfinals (Bo7)
TBD 09:00 UTC The Patriots
TBD 09:00 UTC CHAPATI DREAM
▼ Lower Bracket Semifinal (Bo7)
TBD 10:00 UTC TBD
▼ Upper Final (Bo7)
TBD 10:00 UTC TBD
▼ Lower Final (Bo7)
TBD 11:00 UTC TBD
▼ Grand Final (Bo7)
TBD 12:00 UTC TBD

Standings

Place Prize Team RLCS Points
1st $6,000 TBD +24
2nd $4,000 TBD +20
3rd $2,400 TBD +16
4th $2,000 TBD +13
5th-6th $1,600 TBD +11
5th-6th $1,600 TBD +11
7th-8th $1,200 GracesBlaze +9 (15)
7th-8th $1,200 UHUH +9 (58)
submitted by RLMatchThreads to RocketLeagueEsports [link] [comments]


2023.05.28 09:02 bbyfog [2021 Reich et al, Lancet Neurol] Tolebrutinib phase 2b trial, in relapsing multiple sclerosis

[2021 Reich et al, Lancet Neurol] Tolebrutinib phase 2b trial, in relapsing multiple sclerosis
Tolebrutinib Phase 2b Study
ClinicalTrials.gov number: NCT03889639; EudraCT number: 2018-003927-12
Citation: Reich DS, et al; Tolebrutinib Phase 2b Study Group. Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsing multiple sclerosis: a phase 2b, randomised, double-blind, placebo-controlled trial00237-4/fulltext). Lancet Neurol. 2021 Sep;20(9):729-738. doi: 10.1016/S1474-4422(21)00237-400237-4). PMID: 34418400; PMCID: PMC8434816
STUDY QUESTION OR PURPOSE OF THE TRIAL
To establish safe and efficacious dose of Burton’s tyrosine kinase (BTK) inhibitor tolebrutinib in people with relapsing multiple sclerosis (MS).
BACKGROUND
  • Burton’s tyrosine kinases are nonreceptor kinases expressed in most hematopoietic cells (excluding T cells and plasma cells) that link extracellular cytokines/factors signals with immune cell activation. In the context of MS, BTK signaling is important in B lymphocytes, myeloid cells including peripheral myeloid cells and macrophages, and CNS-resident microglia. (here)
  • The existing MS disease modifying treatments (DMTs) are effective in reducing relapsing rates with annualized release rates if 0.10, in other words, if 10 people are treated with DMTs over a year, only 1 is expected to experience relapse. These DMTs such as ocrelizumab (Ocrevus) affect peripheral adaptive immunity only (peripheral B cells) and do not halt or reverse disability progression. One reason is that they do not target CNS-resident immune cells.
  • Chronic CNS neuroinflammation is thought to contribute to MRI lesions accumulation and disability progression. Currently no approved DMT target CNS immune compartment.
  • BTK inhibitors are CNS-penetrant and, thus, are expected to target both peripheral adaptive immunity as well as CNS-resident immune cells (here).
  • Tolebrutinib binds irreversibly to BTK inhibitor that is given orally. The CNS-penetrant property of tolebrutinib was confirmed in a phase 1 trial in healthy people given a single dose of 120 mg tolebrutinib that achieved therapeutically relevant concentrations in the CSF.
  • This was a phase 2b, randomized, double-blind, placebo-controlled, crossover, dose-finding to establish safe and efficacious dose of tolebrutinib in people with relapsing MS (pwRMS).
WHERE AND HOW
  • The study enrolled 130 pwRMS (aged 18-55 years; EDSS, less than 5.5 at screening) at 40 sites across 10 countries in Europe and the United States. The study included 128 people with relapsing-remitting MS and 2 with secondary progressive MS with relapses.
  • The study participants were randomized 1:1 to 2 cohorts. Within each cohort, participants were randomized 1:1:1:1 to tolebrutinib 5 mg, 15 mg, 30 mg, or 60 mg daily oral dose groups.
  • In cohort 1 (tolebrutinib-to-placebo), all participants first received tolebrutinib at dose according to the group assignment for 12 weeks followed by all participants crossover to 4 weeks of placebo; in cohort 2 (placebo-to-tolebrutinib), all participants first received 4 weeks of placebo following by 12 weeks of tolebrutinib.
-- This unique crossover study design allowed all participants to receive active treatment for 12 weeks, thus, allowing reduction of risk to the patients.
-- The data from the 4-week placebo period from cohort 2 was used as control data in this study. The 4-week placebo run-out period in cohort 1 was used to maintain blind and this data was only used for safety evaluation.
  • The entry criteria required diagnosis of relapsing-remitting MS or secondary progressive MS with relapses; documentation of at least 1 replace in prior 1 year, at least 2 relapses in past 2 years or at least 1 active Gd-enhancing brain lesion in past 6 months prior to screening.
  • The length of the trial was 16 weeks. MRI scans were performed every 4 weeks until the end of study at week 16.
  • The primary objective was to determine the dose-response relationship between tolebrutinib and new active brain lesions detected using MRI. The primary efficacy endpoint was the number of new Gd-enhancing lesions detected on the scan performed after 12 weeks of tolebrutinib treatment (at week 12 for Cohort 1 and week 16 for Cohort 2), relative to the scan 4 weeks prior.
  • Secondary endpoints were the number of new or enlarging T2 lesions detected on the same scan observed after 12 weeks of treatment, the total number of Gd-enhancing lesions after 12 weeks of tolebrutinib treatment (ie, all Gd-enhancing lesions on the scan at the end of 12 weeks of treatment), as well as adverse events (AEs), serious AEs, and AEs of special interest.
RESULTS
  • Baseline characteristics were similar across all groups with mean age of 36 to 39 years; ~66 to 70% female; median time from onset of MS symptoms of ~7.5 years; and mean EDSS score of ~2.5.
  • Median exposure to study drug was ~80 days across four tolebrutinib dose group and 28 days for placebo group. The duration of exposure to active study drug was 12 weeks.
  • Primary endpoint: using an exponential model, a dose-response relationship was observed between tolebrutinib and new Gd-enhancing lesions (p=0.03). The 60-mg dose showed maximal effect with 85% reduction (95% CI, 28–97%) in new Gd-enhancing lesions versus placebo after 12 weeks of treatment.
  • The mean ± SD number of lesions was 0·13 ± 0·43 for tolebrutinib 60 mg versus 1·03 ± 2·50 for placebo.

Tolebrutinib Phase 2b Study: Figure, primary endpoint
  • Secondary endpoints: dose-response relationship for the number of new or enlarging T2 lesions was established (p <0.0001). A maximal effect was again observed with the 60-mg dose, with an 89% (95% CI, 68–96%) versus placebo.
  • Safety: Headache was the most common nonserious adverse event.
CONCLUSIONS
  • The primary objective of the trial was met and the null hypothesis of a flat dose-response curve was rejected.
  • The 60 mg dose was most efficacious in reducing acute inflammation in brain (new Gd-enhancing lesions). Reduction in new Gd-enhancing and/or enlarging T2 lesions is established in literature to correlate with reduction in relapse rates; this provides rationale to further study tolebrutinib in larger MS trials.
  • Currently following tolebrutinib MS trials are ongoing: long-term safety study NCT03996291) and phase 3 studies including in relapsing MS (NCT04410978 and NCT04410991), PPMS (NCT04458051), and nonrelapsing SPMS (NCT04411641).

Related: BTK inhibitors for MS, FENopta trial
submitted by bbyfog to MultipleSclerosisLit [link] [comments]


2023.05.28 08:59 LambdaPhi13 Nightmare blunt rotation

Nightmare blunt rotation submitted by LambdaPhi13 to imaginaryelections [link] [comments]


2023.05.28 08:57 Sgabonna Measuring Good and Evil - Example Hitler's World War 2. (1st Attempt)

I've given instructions to ChatGPT to assess all the Positive and Negative wills that can derive 'Good' and 'Evil' actions. As well as given a point system in which it can assess Good and Evil.
Here is my first proper assessment of an event. What tweaks would you want?
Let's start with the Evil assessment:
  1. Magnitude of harm based on action (0-10 points): Hitler's actions resulted in the death of 6 million Jews during the Holocaust, in addition to causing World War II, which resulted in the deaths of an estimated 70-85 million people (approximately 3-4% of the world's population at the time). Thus, the magnitude of harm is clearly at a maximum of -10 points.
  2. Multiplier for the number of individuals affected (1-10): Given the vast number of people affected both directly (through war and genocide) and indirectly (through the widespread devastation of communities and nations), this would also be a maximum of -10.
  3. Duration (0-10 points): Hitler's reign lasted for 12 years (1933-1945), during which his harmful actions were continual. Therefore, this earns -10 points.
  4. Intentionality (0-10 points): Hitler was fully aware and intentional in his harmful actions, thus scoring another -10 points.
  5. Degree of self-interest (0-10 points): Hitler's actions were driven by a warped sense of nationalistic pride and a desire for personal power and dominance, indicating a high degree of self-interest. This results in another -10 points.
  6. Impact on vulnerable populations (0-10 points): His actions targeted multiple vulnerable groups, including Jews, the disabled, and political dissidents, among others. This would result in a maximum score of -10 points.
Weighted harm score = Magnitude of harm (-10) x Multiplier for individuals affected (10) = -100 points Total Evil score = Weighted harm score (-100) + Duration (-10) + Intentionality (-10) + Degree of self-interest (-10) + Impact on vulnerable populations (-10) = -140 points
Now, for the Good assessment from Hitler's perspective:
  1. Magnitude of self-sacrifice (0-10 points): Hitler may have seen himself as making personal sacrifices for what he saw as the "greater good" of his vision for Germany. However, this was deeply intertwined with his desire for personal power. Therefore, he might be given 2 points.
  2. Magnitude of reducing suffering/increasing pleasure (0-10 points): Hitler did initiate policies that led to economic recovery and reduced unemployment in Germany, which in his view could be seen as reducing suffering/increasing pleasure for some. However, these actions were significantly outweighed by the immense suffering he caused. Therefore, he might be given 1 point.
  3. Multiplier for the number of individuals benefiting (0-10 points): The number of individuals that benefited from Hitler's actions would be small compared to those harmed. However, in his mind, he may have seen the German people as beneficiaries. Therefore, he might be given 1 point.
  4. Magnitude of selfless motivation (0-10 points): Hitler’s motivations were primarily based on a destructive ideology, personal power, and dominance rather than selflessness. Therefore, he gets 0 points.
  5. Duration of the behavior (0-10 points): Hitler held power for 12 years. However, considering the detrimental impact of his actions, duration doesn't translate into positive points here. Therefore, he gets 0 points.
  6. Intentionality (0-10 points): Hitler was highly intentional in his actions, but considering his intentions were mostly harmful, he doesn't gain positive points for intentionality. Therefore, he gets 0 points.
Weighted benefit score = 2 (Self-sacrifice) + 1 (Reducing suffering) + 1 (Multiplier) + 0 (Selfless motivation) + 0 (Duration) + 0 (Intentionality) = +4 points
Therefore, Hitler's combined score, based on your suggested calculation method, would be -140 (Evil) + 4 (Good) = -136 points.
Please note that this assessment is based on the scales and values you provided and is intended for illustrative purposes. It does not take into account all the complexities and nuances of historical events or human behavior, nor does it aim to diminish the horrific atrocities committed during Hitler's regime.
Everything that we do to hurt one another comes from a perceived animalistic concept of 'Us' vs 'Them'. It is a curse that begets humanity, just as it does the animal kingdom. We want to feel like we belong, we are born alone, we are self aware, so we group. But groupings creates a sense of 'Us', and to protect 'Us', we can justify doing EVIL things to 'them'. War is just politically sanctioned 'Murder', and 'self defence' which turns into offense, continues the cycle of 'Murder' through revenge.

Competing Wills

Positive Wills (from Hitler's perspective): Negative Wills:
Will to Power (Nietzsche): Hitler sought power over Germany and subsequently Europe. He desired domination and control, an extreme and perverted interpretation of Nietzsche's concept of the Will to Power. Will to Dominate: Hitler wanted to impose his will on others, not for their benefit, but to exert control and power.
Will to Lead: Hitler certainly had a strong will to lead and command, which he demonstrated as the Führer of Nazi Germany. Will to Deceive: Hitler used propaganda to manipulate public opinion and deceive not only his own people but also the international community.
Will to Innovate: Hitler pushed for technological and infrastructural advancements, such as the development of the Autobahn, V2 rockets, and jet aircraft. Will to Destroy: Hitler sought to destroy entire races and cultures in his pursuit of the so-called Aryan supremacy.
Will to Achieve: Hitler had a strong will to achieve his goals, however warped and destructive those goals were. Will to Intimidate: Hitler used fear and intimidation as tools to silence opposition and maintain control.
Will to Assertiveness: Hitler was certainly assertive, often aggressively so, in pushing his policies and ideology. Will to Hate: Hitler harbored and incited extreme hatred towards Jews, Slavs, Romani people, disabled individuals, and other groups.
Will to Order: Hitler had a vision for an orderly society, structured according to his racist and xenophobic ideologies. This pursuit of order, however, was achieved through violent and oppressive means. Will to Exploit: Hitler exploited not only the people he persecuted but also the German people and their nationalistic sentiments.
Will to Protect: Hitler often justified his actions as necessary to protect the Aryan race and German society from what he perceived as external threats (other races, cultures, political ideologies, etc.), even though this "protection" resulted in unimaginable harm and destruction. Will to Kill: This is the most grave and severe will, which led to the genocide of six million Jews during the Holocaust, along with countless others who perished during World War II.
Will to Loyalty: He exhibited a perverse form of loyalty towards his vision of the German people and the Aryan race. This sense of loyalty was skewed towards those who adhered to his ideologies and were of perceived racial purity. Will to Reject: Hitler rejected the notion of equality among races and cultures, leading to his pursuit of an Aryan "master race."
Will to Unity: Hitler aimed to unite the German people under a single ideology, a warped form of nationalism. Unfortunately, this unity was achieved through manipulation, propaganda, and force. Will to Isolate: Hitler implemented policies that isolated targeted groups, particularly Jews, from the rest of society, as seen in the establishment of ghettos and concentration camps.
Will to Prosperity: Hitler sought economic prosperity for Germany, which was still recovering from the Treaty of Versailles. However, this prosperity was pursued at the expense of marginalized and oppressed groups. Will to Subjugate: Hitler aimed to subjugate other nations under German rule, reflecting his ambition for imperial conquest.
Will to Tradition: Hitler emphasized the importance of tradition and heritage, but he did so in a way that selectively glorified certain aspects of German history while demonizing others based on his prejudices. Will to Defile: Hitler not only physically defiled groups he saw as inferior, but also morally and spiritually defiled them in his speeches and propaganda.
Will to Neglect: Hitler showed an extreme lack of compassion or empathy towards the people he harmed, reflecting a severe form of neglect.
Will to Disregard: Hitler disregarded the rights, dignity, and value of the lives of those he deemed inferior or undeserving.
Will to Oppress: Hitler exerted control through oppressive measures, denying basic human rights and freedoms to those under his rule.
Will to Conformity: Hitler forced his ideologies onto the German people, expecting conformity and submission to his vision for the nation and the Aryan race.
Will to Envy: Hitler's policies and actions might reflect an underlying envy towards the groups he targeted, perhaps seeing their cultural, intellectual, or economic successes as threats to his vision of German superiority.
Will to Arrogance: Hitler's actions and speeches often conveyed an inflated sense of self-importance and an unwarranted feeling of superiority over others, hallmarks of arrogance.
Will to Ignorance: Hitler embraced and propagated ignorance, denying factual information that contradicted his ideologies, as seen in the distortion of scientific, historical, and cultural facts in Nazi propaganda.
submitted by Sgabonna to JordanPeterson [link] [comments]


2023.05.28 08:56 FoundationBudget531 Clean Yacht Master

Clean Yacht Master
  1. Dealer name: Steve
  2. Factory name: Clean
  3. Model name (& version number): YM 126622
  4. Price paid: $498 shipped
  5. Album Links:
  6. Index alignment: looks good to me, however maybe the rehaut is a tad bit off? Acceptable however.
  7. Dial Printing: looks good
  8. Date Wheel alignment/printing: maybe little low? Still acceptable
  9. Hand Alignment: looks good to me
  10. Bezel: all good
  11. Solid End Links (SELs): Good
  12. Timegrapher numbers: don't really know much about this, thinks it's ok? Nothing special but not bad.
  13. Anything else you notice: no nothing accept the rehaut and date aren't perfect. But acceptable to me. Just trying to get better at qc'ing. Hope you guys agree with my findings.
submitted by FoundationBudget531 to RepTimeQC [link] [comments]


2023.05.28 08:55 Accomplished-Ask-390 this is insane someone look into this, its not ok this is allowed

this is insane someone look into this, its not ok this is allowed submitted by Accomplished-Ask-390 to FACEITcom [link] [comments]


2023.05.28 08:54 Jay-4-Real automatically create new sheets with formatted tables, from a list,

Hi
I am wanting to know how I can take a table with data, and create multiple new sheets, with each sheet being named from a rows in colum A, and with in each sheet, have table created that has data filled in from the other colums, below is a example of the kind of table i would start with and the right hand side is new sheet.
I would like to create 6 new sheets each with a table already made and the information populated.
thank you in advance anyone that helps

https://preview.redd.it/ym3t3eynri2b1.png?width=1175&format=png&auto=webp&s=81461c5573a939e2fc136cf4946294e8320babe4
submitted by Jay-4-Real to excel [link] [comments]


2023.05.28 08:52 Square_Ad43 Seeking advice on Real Estate Investing: Here's my situation!

Over the past couple years I've had in built in my head that I was going to go all in on getting my 1st rental property. The more I've analyzed the situation the more I'm seconding guessing myself. What is the right way to go about investing in my first property? Here is some numbers on the first property I may buy. Listed at: $159,990 Interest rate: 8.76% due to LLC or it would be 6.76% under my name Monthly Mortgage rate approx: $1288/month with 20% down or $1485/ month with 10% down. Home Information: 3 bedroom, 1 bath, 1114 sqft. - recently renovated If I put 20% down I would net approx. : $156/ month until rates drop and I'm able to refinance. Here's where I get stomped Do I dish out a huge chunk of money for a downpayment to make a small amount of profit each month? If, so it will take me still about 5 years to break even with my downpayment expense. I feel like I really want to buy a property just because I've been itching to for years and I know in the long-term it could be very good in profits. 5 years is awhile to break even and large chunk of money up front that could be used on other investments! Right now I have $15k invested in a real estate stock that pays me $250/month in dividends but I'm currently down $4k over real but I still get a bigger cash flow than what I would in physical real estate investing. Do I benefit more from physically investing in real estate or would I benefit more from investing in the real estate stock? I feel like I've missed out on a couple of good deals due to me not being able to pull the trigger on a rental property but then again my cash flow would be so minimal in the beginning I'm not sure if its worth it.
submitted by Square_Ad43 to RealEstate [link] [comments]


2023.05.28 08:45 PurpleSolitudes Best Gaming Routers In USA Available on Amazon

Best Gaming Routers In USA Available on Amazon

Gaming routers are designed to provide a better online gaming experience by reducing lag and improving latency. If you are a serious online gamer, then a gaming router can be a worthwhile investment. It can help to improve your gaming experience and reduce lag, which can give you a competitive edge.
Benefits of Using a Gaming Router:
  • Reduced lag: Lag is the delay between when you press a button on your controller or keyboard and when the action is reflected on the screen. Gaming routers can help to reduce lag by optimizing your network and prioritizing gaming traffic.
  • Improved latency: Latency is the time it takes for data to travel from your computer to the game server. Gaming routers can help to improve latency by using a variety of techniques, such as reducing the distance between your computer and the game server.
  • Faster speeds: Gaming routers typically have faster processors and more memory than traditional routers, which allows them to handle more data at once. This can lead to faster download speeds and less lag during online gaming.
  • Better range: Gaming routers often have more powerful antennas than traditional routers, which can extend the range of your Wi-Fi network. This can be helpful if you have a large home or if you live in an area with a lot of interference.
Advanced security features: Gaming routers often have more advanced security features than traditional routers. This can help to protect your network from hackers and other online threats.

Asus ROG Strix GS-AX5400


https://preview.redd.it/j8k608mn9b2b1.png?width=1500&format=png&auto=webp&s=b384e17f10f1cd7e0193f3022a06ca46e1ff803a
The Asus ROG Strix GS-AX5400 is a Wi-Fi 6 gaming router that offers a number of features designed to improve your online gaming experience. These features include Read More

TP-Link AC4000 MU-MIMO Tri-Band WiFi Router (Archer A20)


https://preview.redd.it/v382vlfo9b2b1.png?width=1500&format=png&auto=webp&s=fe9f2760571afe0b767fc2dd416e510150023343
The TP-Link Archer A20 is a tri-band Wi-Fi router that offers a number of features designed to improve your home network. These features include Read More

Netgear Nighthawk Tri-Band Wi-Fi 6E Router (RAXE500)


https://preview.redd.it/k0qopvep9b2b1.png?width=1380&format=png&auto=webp&s=05fc27a3d3cc49771b5c8995e27e97dd01b8ca0e
The Netgear Nighthawk RAXE500 is a tri-band Wi-Fi 6E router that offers a number of features designed to improve your home network. These features include Read More

TP-Link Archer AX50 (AX3000) Dual Band Gigabit Wi-Fi 6 Router


https://preview.redd.it/6frsn0aq9b2b1.png?width=1500&format=png&auto=webp&s=b9fbf769eff82b22914bcb87264eab20526fe77b
The TP-Link Archer AX50 is a dual-band Wi-Fi 6 router that offers a number of features designed to improve your home network. These features include Read More
submitted by PurpleSolitudes to allinsolution [link] [comments]


2023.05.28 08:43 LargeSizedAmmunition A new faction rises (homebrew faction, get hyped)

A new faction rises (homebrew faction, get hyped)
A new faction has joined the world stage.

An exploration of the Imperium of man have encountered a new species known as the psions.
These "Psions" are reptilian humanoids with large purple eyes and strange bat-like noses, while the patrol initially dismissed them as primitive, they were soon met by ships of the Psion National Defense Flotilla who after a brief stand off, successfully convinced imperial forces to withdraw peacefully. While not much is known about the psions so far, beyond the following:

  1. they are some form of authoritarian state
  2. they are familiar with humanity
  3. they are staunchly supremacist
  4. they have a capable military but exact numbers are unknown
  5. some are capable of seemingly magical feats despite not having any significant warp presence
  6. they have no desire for war (at least not yet)

(I might make a post detailing more of them later but for now I just want to get an introduction)
Glorious psion flag
submitted by LargeSizedAmmunition to MultiverseOfWar [link] [comments]


2023.05.28 08:40 html_lmth Cantonese written in Arabic script BECAUSE WHY NOT

Cantonese written in Arabic script BECAUSE WHY NOT
Consonants
These are rather straight forward, just one symbol for one consonant. Most of them follow the original Arabic pronunciation with a few exceptions.
https://preview.redd.it/stu5u7o26k2b1.png?width=454&format=png&auto=webp&s=e30b6c3e9a5b20fe7a6079cfb6b7b09039864667
Vowels
I am not going to explain every detail in this table, but there is a few things to note:
  1. Long vowels are always written in full form, while short vowels are written in diacritics most of the time. This is also the reason why I did not use Jyutping here.
  2. For [-p], [-t] and [-k], I chose [-b], [-d] and [-g] instead, mostly because [p] is not a sound in Arabic.
  3. I put [jung] as a combination of [y] and [-ng] here. This syllable only exists when there is no preceding consonant, but it is still possible to have this syllable not at the initial position, for example “作用” would be خاْقیُغ . It is placed in the table only to demonstrate the coherent of the system, as it would be the same spelling if you consider that as [j]+[-ung]

https://preview.redd.it/rx4eu7cj6k2b1.png?width=644&format=png&auto=webp&s=54109b0799b5284f0b2593bdf6d201f3ce606f07
https://preview.redd.it/z8somopl6k2b1.png?width=642&format=png&auto=webp&s=482a4e59db4e1f1629d10f6d66ea0756861be077
Example 1: Article 1 of the Universal Declaration of Human Rights
人人生而自由,在尊嚴和權利上一律平等。他們賦有理性和良心,並應以兄弟關係的精神互相對待。
« یَنیَن سَغ ی خییَو،خاْی خیُنیم واْ کیُنلِی سعغ یَدلَد پِغدَغ. تامون فویَو لِیسَغ واْ لعغسَم، بِغ یَغ ی حَغدِی قوانحَی دِق خِغسَن وسعغ دٔیُ داْی. »
Example 2: Dialogues from Stephen Chow’s movie “Flirting Scholar”
冚家鏟泥齊種樹,汝家池塘多鮫魚。
魚肥果熟嫲捻飯,你老母兮親下廚。
« حَمقا ثاننَی ثَی خُغسیُ، یُقا ثیتاْغ داْ قاویُ. یُفِی قواْسُق ما لَمفان، نِی لُومُو حَی ثَن حاثیُ. »
Introduction
I should put the following on top of the tables, but I know how Reddits work, you are not going to read these.
Recently, there is a lot of posts about using alternative writing system for Cantonese, including but not limited to Taiwanese Bopomofo, Korean Hangul, or even just reworking on different way of writing Cantonese in Latin alphabets. Out of the pure love for Cantonese (and because I have no life), I decided to create a series of different writing system for Cantonese, with various level of complexity. For all the linguistic nerds out there, get ready for the numerous treats (or disastrous designs) in the next couple weeks (or months, or years, I don’t know if I will commit to it at all LOL).
Why creating a new writing system? Philosophies behind the design.
The biggest reason is of course “For fun”, but if there is any practical reason behind this, it would be “to allow foreign speakers to learn Cantonese easily”. While Jyutping is simple and logical, humans aren’t. Human tend to learn with intuition and based on what they already knew (I should really cite some pedagogical theory here but this would be taken too far, just trust me). This is also why I start my series from Arabic abjads, because this is the third most widely used scripts by number of users in the world (after Latin alphabets and Chinese scripts).
For this reason, my main philosophy in designing the new system would be “to be as intuitive as possible for foreign learners”. Matching the alphabets and the rules of the original script as close as possible while being logical and consistent within the system would be my goal. It is not meant to be a replacement to the original Chinese script.
Is there any other reason to create a new writing system? For me, not really, but for some it can be political. Although I have no evidence of it, there are hints on anti-Sinitic sentiments behind some of the related posts. Just to make it clear, I am not sold on abandoning Chinese scripts for Cantonese, but that is the story for another time.
Basic feature of Arabic script:
(1) Arabic script, or “Abjads”, is written from right-to-left.
(2) There are no capital or small letters, but each letter has different forms depending on the position. For example, the letter for “B” is ب when standing alone, but “BBB” is written as ببب , which shows how “B” appears in initial, medial and final position of a word.
(3) In Arabic, only long vowels are written, and short vowels are omitted, with diacritics as “backup plan” in case there is a need to clarify the vowels. In the following system, some vowels will be considered as short vowels and are written as diacritics, although they are obviously not negligible.
Arabic script in other Chinese languages: Xiao’erjing or Xiaojing
The greatest difficulty in creating an Arabic Cantonese script is the limited letters for vowels in the script, so I tried to look for reference in how they adapt Arabic script in other languages. To my surprise, or maybe I should not be surprise at all, there is a long history of writing Chinese in Arabic, mostly for the Huis and Uyghurs nowadays.
The system is super messy, especially for the vowels. Some vowels can have more than one form depending on the preceding consonants, and some forms can mean different vowels depending on consonants. That being said, I still find some inspiration out of it, especially on the use of diacritics for vowels.
Limitation
The writing system is not going to write down the tone. I tried to find examples from other languages, and apparently, they write down the tone in Rohingya language using Arabic script, but my computer cannot show them properly. With all the diacritics flying around the words, I don’t think there is an elegant solution for tone without introducing new stuff, and that would be too difficult to type, so I just completely ignore them.
submitted by html_lmth to Cantonese [link] [comments]


2023.05.28 08:39 weuoimi Please help me to solve the package conflict

so. here is the problem:
sudo dnf update Fedora 38 - x86_64 - Updates 6.6 kB/s 14 kB 00:02 Fedora 38 - x86_64 - Updates 196 kB/s 495 kB 00:02 Fedora Modular 38 - x86_64 - Updates 22 kB/s 18 kB 00:00 download.vscodium.com 606 B/s 866 B 00:01 Dependencies resolved. Problem: both package pipewire-jack-audio-connection-kit-0.3.71-2.fc38.x86_64 from updates and jack-audio-connection-kit-1.9.22-1.fc38.x86_64 from fedora obsolete jack-audio-connection-kit-example-clients < 1.9.22 - package pipewire-jack-audio-connection-kit-0.3.71-2.fc38.x86_64 from updates conflicts with jack-audio-connection-kit provided by jack-audio-connection-kit-1.9.22-1.fc38.x86_64 from fedora - cannot install the best update candidate for package pipewire-jack-audio-connection-kit-0.3.67-1.fc38.x86_64 ================================================================================ Package Arch Version Repo Size ================================================================================ Skipping packages with conflicts: (add '--best --allowerasing' to command line to force their upgrade): jack-audio-connection-kit x86_64 1.9.22-1.fc38 fedora 527 k pipewire-jack-audio-connection-kit x86_64 0.3.71-2.fc38 updates 140 k Transaction Summary ================================================================================ Skip 2 Packages Nothing to do. Complete! 
i tried to remove jack-audio-connection-kit, but it just wont work!
$ sudo dnf remove jack-audio-connection-kit-1.9.22 No match for argument: jack-audio-connection-kit-1.9.22 No packages marked for removal. Dependencies resolved. Nothing to do. Complete! $ sudo dnf remove jack-audio-connection-kit-1.9.22-1.fc38.x86_64 No match for argument: jack-audio-connection-kit-1.9.22-1.fc38.x86_64 No packages marked for removal. Dependencies resolved. Nothing to do. Complete! $ sudo dnf remove jack-audio-connection-kit-dbus.x86_64 No match for argument: jack-audio-connection-kit-dbus.x86_64 No packages marked for removal. Dependencies resolved. Nothing to do. $ sudo yum erase jack-audio-connection-kit.i686 No match for argument: jack-audio-connection-kit.i686 No packages marked for removal. Dependencies resolved. Nothing to do. Complete! $ sudo dnf remove jack-audio-connection-kit No match for argument: jack-audio-connection-kit No packages marked for removal. Dependencies resolved. Nothing to do. Complete! 
--best --allowerasing also don't work in my case, maybe i am using it wrong?
please let me know what you do in these cases
submitted by weuoimi to Fedora [link] [comments]


2023.05.28 08:37 jrhLIVE WTF in river oaks

WTF in river oaks submitted by jrhLIVE to ClassicBroncos [link] [comments]